Chapter 185 Passivation Plan
Hu Xinxi scratched her head and said: "If it is too late to change the kettle, then we will temporarily use the substitution method to turn the stainless steel kettle into an enamel kettle. It can't be said to be an enamel cauldron. It should be considered a stainless steel cauldron turned into an acid-resistant cauldron as a delaying measure."
Feng Huishan said: "Can you tell me about it?"
"Use nitric acid to passivate the surface layer inside the stainless steel kettle to form an oxide film. This oxide film can block the acid that steel and iron are most afraid of! This knowledge was mentioned in junior high school chemistry. Since the kettle cannot be replaced, , then just do it like this. The whole operation can be completed in half a day without delaying the progress of the entire plan. Can you see if it works?"
Feng Huishan thought for a while: "That's a way. ! But you still seem to suspect that the cauldron is the problem!"
"Yes, we will input the overall parameters of the vaccine into Li Ruiya's model to see if there is any warning in the final response of her model? If there is a serious warning, then I am 100% sure that the culprit of this reaction failure is the iron ions in the stainless steel reactor, because during the entire process of adding acid in the middle, the system is acidic for a period of time, and it is precisely this acidity that will This causes the iron ions in the stainless steel reactor to rise sharply, and the characteristics of this vaccine seem to be very afraid of metal ions, which will cause the vaccine to complex with it and not be able to work!”
After listening to Hu Xinxi’s professional explanation! .
The process supervisor suddenly remembered this risk.
Then he hesitated and said: "Director Hu is right. We have considered this risk in the early stage, but felt that the impact would not be that big, so we did not regard it as a key electrical point. Now after Hu When Xinxi said this, I felt that Hu Xinxi's analysis was correct, especially in the field of biomedicine. Various proteins will be slowly formed in the process. Proteins can easily complex with metal ions, which will affect the finished product in an instant. It has a fatal impact!"
Feng Huishan sighed after hearing this.
"Then when Hu Xinxi raised this issue, why did you refuse to change the cauldron?"
He Mufeng said: "We also thought at the time that it was just a short-term acidic environment. When acid splashes, part of the acid will continue to react with the stainless steel reactor, causing a large amount of iron ions to appear in the back. "
Feng Huishan asked Fu Ping, the equipment manager.
"Fu Ping? The problem is with you. You are the equipment supervisor. How can you avoid this kind of problem on the equipment? Do you have any good cases here!"
Fu Ping said: "This situation does exist in reality. The most fundamental way to prevent this phenomenon is to change the cauldron. Time certainly does not allow it now, so we will try according to Director Hu's method. I I feel that the passivation process is very reliable. At the same time, after adding the acid, we use a pump to circulate the material, and use a spray device to circulate the material in the kettle.Mix evenly in every corner to ensure that the acid solution and alkali solution are fully mixed. These two measures should avoid the production of a large amount of iron ions in the system! "
Feng Huishan nodded with satisfaction.
"How long will such rectification take? "
Fu Ping said: "This is quick. The pump and sprinkler system are available in the warehouse. It will take two hours to replace them! In addition, if the equipment is passivated, it should be no problem that the entire transformation and treatment process will take one and a half days! "
After Feng Huishan heard this, he recorded it in his notebook. He calculated the construction period again. If he was delayed for half a day, it would be difficult to get stuck in the subsequent time, and the worker's operating rhythm would change. If he was delayed, If it takes one day, the rhythm can be stuck, but the time is too long. Feng Huishan urgently needs to show results in test runs to prove his usefulness, so in his mind, he wants to have the best of both worlds without delaying the construction period and implementing the transformation. method.
So he asked Hu Xinxi
"Director Hu, are there any other ways to shorten the time without affecting the entire construction period? "
Hu Xinxi said: "This is true, that is, we do not need to wait for the inspection results before proceeding to the next step. In this way, the construction period can be shortened by two days, which can just make up for the one day of delay, and the test run can be completed in advance. , but most of the processes that don’t wait for the results to come out before investing are based on mature processes. Most people don’t dare to test the process. However, if Li Ruiya’s modeling is successful, the chemical and biological properties of each intermediate can be analyzed. If no warning is issued when entering the model, I can guarantee that the intermediate sampling results will definitely pass! This also fully shows that modeling actually plays a decisive role in the entire process! "
Feng Huishan said to the process supervisor and Li Ruiya: "How is it? To implement Hu Xinxi's plan, the two of you cooperated with the chemical parameters and process parameters of the process intermediates to make the model complete and run without warning! It has to be done tonight! "
Then Duan Ping and Hu Xinxi said: "You two are responsible for the transformation of the equipment and the passivation of the stainless steel reactor. It will be carried out immediately. The chemical inspection will be carried out normally, but there is no need to wait for the results on the production side. , proceed to the next step as soon as the intermediate comes out! "
Hu Xinxi and Fu Ping agreed: "Okay! "
Finally, Feng Huishan said to Ping: "At Beth Pharmaceuticals, please notify Li Tao and follow this plan. I will leave a backup of today's video conference and send the content of the meeting to Li Tao. Let him follow it and synchronize with our plan! "
Fu Ping replied: "Okay! I'll let you know! "
Feng Huishan was under tremendous pressure and finished the video conference. She was extremely depressed, but there was no other way. He was still regretting the decision to take his sister to Lianhai City. He didn't expect that his sister would is the biggest unsafe factor. Although he intended to bring his sister and Captain Zhao together at the time, he didn't expect that they would go behind his back.When she is pregnant with a child, the most critical issue is to let Fenglong know. Otherwise, he wouldn't be under such great pressure.
Fortunately, Feng Huishan did not give up on himself. He quickly found the best plan and prepared for the next round of test runs.
After the meeting, Hu Xinxi called Manager Wang.
"Manager Wang, have you got any results from the stability test of your small trial?"
At this time, Manager Wang is looking at the various data of the test, especially the stability Post-test data.
Manager Wang looked at the computer report and said to the phone: "The data here are very good. After the first sampling and stability test, the content was basically maintained at the same level, and basically no tension occurred. Degradation."
Hu Xinxi's brow relaxed slightly.
"What kind of reactor are you using!"
Manager Wang opened his mouth wide and said in an incredible tone: "Are you stupid? You have been in the laboratory for so long before. , How long have you been out, have you forgotten even the most basic reactor? We usually use glass instruments, and most of them use three-necked flasks. Are you Hu Xinxi?"
Hu Xinxi ignored him.
He continued to ask: "Where is the stirrer?"
"Just use the usual PTFE stirrer!"
Hu Xinxi said: " I understand. You should continue testing according to the established goals. There is something wrong with our large-scale production. Maybe it is related to ionic compounds?"
Manager Wang sighed.
"That's not right. It stands to reason that there won't be much of a problem in my small trial, and there shouldn't be any major problems in your large-scale production. If there is a problem, it will be unless there is a problem with the equipment and there is no corresponding system."
Hu Xinxi said: "Actually, I should have come to supervise the work earlier. Due to the negligence of the construction party and the process supervisor, their equipment selection was a bit unsatisfactory. They actually used a stainless steel reactor to react to the problems that were put in during the process. Acidic materials will inevitably bring in related ionic compounds!"
Manager Wang laughed.
"You can make such low-level mistakes? Your process supervisor is not good at it!"
Hu Xinxi said: "Actually, you can't blame the process supervisor, he has just arrived. The time here is very short. The main reason is that there was no one to check this project from the beginning. When I took over, they had already installed the equipment! If they wanted to switch to an enamel kettle, the construction period would be delayed by at least four to five days. , Feng Huishan disagreed, so she asked me how to shorten the construction period."
Manager Wang thought it was reasonable.
Dangjian said: "Don't worry, I haven't had any failures yet! The intermediate in our small trial can reach a content of 96%, which is absolutely high-yield, and the stability test There has been no change since then. Therefore, the root cause of your test run failure is undoubtedly the stainless steel reaction.The problem of the cauldron. "
Hu Xinxi said: "It should be like this. I will input the relevant parameters of the vaccine into Li Ruiya's modeling later. If no corresponding warning is issued, our intermediate will not After sampling, go directly to the next step! When the time comes, you can provide me with the data so that I can have a better idea! "
Manager Wang smiled and said: "I am happy to help! Don’t worry, as long as a test result appears here, I will send it to you so that you can have a reference and comparison! "
Hu Xinxi smiled.
"This is my Manager Wang! "
Manager Wang shook his head quickly.
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"Don't dare! Don't dare! You are Assistant Hu now, you are my leader, just call me Xiao Wang from now on! "
The two exchanged greetings. After hanging up the phone, they were busy with their own affairs.
With Manager Wang as her backing, Hu Xinxi was full of confidence. Immediately started to communicate about the necessary nitric acid and equipment, and prepared to start passivating the reactor tomorrow.
And other people were also busy
Soon Feng Huishan came up with one. file, called Li Ruiya to Hu Xinxi's office
He thought for a moment and finally decided to spread the document containing the chemical formula of the vaccine on Hu Xinxi's desk.
Pointing to the chemical formula in the document, he said: "This chemical formula is very complex. It is a protein cluster, an active protein cluster. You can use the model to deduce the properties of this protein cluster. There is also a corresponding introduction at the bottom of the document, but I will not comment on it if it is not complete. Got it, you watch and make models! "
Li Ruiya looked at the chemical formula. Is there any real-life encyclopedia for this protein mass?"
Feng Huishan shook her head: "No!"
Hu Xin Xi said: "If not, the controllable risk would be huge!"
Feng Huishan said: "But I heard my father say that it is an inactivated virus vaccine, similar to the flu vaccine , the specific characteristics also refer to the characteristics of the influenza vaccine!"
Hu Xinxi said: "Okay! Let's give it a try first!"
Li Ruiya also agreed: " Okay! Let’s give it a try! Can you give us a copy of your material?”
Feng Huishan was a little embarrassed.
He whispered: "My father has warned me many times not to disclose the chemical structure of this vaccine until the last minute. I'm afraid it won't be convenient for you to give the information. If you want to see it, you can take a photo. Take a look at the photo. Please keep this original copy with me for the time being. The main reason is to avoid leaking secrets. If competitors know the chemical formula and structure, and they successfully test the vaccine before us, then our two production lines during this period can be regarded as It's all in vain, the risk is too great, even if I believe in you so much, thisI can’t give you the original. Do you know what that means? "
Hu Xinxi and Li Ruiya nodded.
"Understood! Thank you for your trust! "
Feng Huishan finally emphasized.
"You have taken photos and entered the relevant parameters into the model, and you must delete the photos! I absolutely believe in you, and I hope you will follow it! "
Li Ruiya said: "Don't worry! We are not that kind of people. After I read it, I deleted it immediately! "
Hu Xinxi said: "That's right! Don't worry! "
The two people's seemingly tacit responses made both of them feel very embarrassed.
When their eyes collided, they quickly lowered their heads.
Feng Hui Shandao: "That's good! Of course I choose to believe you, don’t be too tired, there is still a lot of work to do in the future? "
After a brief communication.
After Feng Huishan left, Li Ruiya entered the information in the photo into the model. As soon as she entered it, she saw a red glare coming from Li Ruiya's model.
Hu Xinxi quickly stepped forward to check Li Ruiya's computer.
The alarm message read: "Metal ions exceed the standard. Please operate with caution. It is recommended to replace the stainless steel reactor!" "
Hu Xinxi cursed secretly: "Sure enough, it's the stainless steel reactor that's weird! But your model is really good, and it gives us an early warning! "
Li Ruiya said: "Otherwise, I wouldn't have won the championship! "
Hu Xinxi smiled and said: "Are you and Jiao Zhe developing?
Li Ruiya shook her head: "Don't mention feelings at work, just like you and Zhong Yu!" "
Hu Xinxi didn't know how to answer.
The last sentence came out.
"It's getting late. Be careful when you go back and rest early. There will be more tomorrow. How much to do? "
Li Ruiya forced a smile.
"Same for you! "
He Mufeng and Fu Ping were chatting together.
He Mufeng said: "This Hu Xinxi really has two brushes. She found the problem so quickly, and she had it before the test run. I used to look down on him for such a prediction, but the passivation plan he proposed today makes me admire him greatly! "
Fu Ping said: "He must be talented, otherwise Fenglong would let him be the technical director here! But what a pity, too many people want his life! "
He Mufeng covered her mouth.
"You have to be careful, lest the walls have ears! "
Hu Xinxi did not go home after get off work. He drove to the police station and was going to ask Xiao Liu to get some information about Captain Zhao's previous case.
Unexpectedly, the person who received him It’s Jin Xin
“You are Captain Zhao’s friend! "
Hu Xinxi nodded.
"Who are you? I've never seen you before?"
Jin Xin said: "The new captain, before Captain Zhao goes into confinement, I will be in charge of all matters here for the time being. Host, what's the matter with you?"
Hu Xinxi covered her mouth and nose.
Said: "Captain Zhao?"
Jin Xin immediately interrupted Hu Xinxi.
"There is no need to discuss anything about Captain Zhao. This is an order from our superiors, and we, as subordinates, must carry it out!"