When it comes to medication, Li Shizhen was quite happy at first, because he already had quite a collection of manuscripts, namely the legendary Compendium of Materia Medica, but now Li Shizhen is not happy at all.
Because the current Compendium of Materia Medica still lacks enough repeated experiments, it inevitably contains quite a lot of legendary prescriptions. I didn't think the problem was that big before. After all, this is how medical books have always been written. However, after comparing the newly compiled records to clear up wrongdoings, Li Shizhen found that her own manuscripts were almost useless.
Looking at Li Shizhen’s expression of embarrassment, Gao Hanwen asked curiously, “Miracle Doctor Li, are there any difficulties?”
“Of course there are difficulties, and that is the current repeated experiments on the efficacy of the medicine. Not enough. To obtain sufficient repeated test statistics, we need the joint support of large pharmacies or even multiple pharmacies. But in our industry, we all think that we are miracle doctors. It is so difficult to jointly test medicines and prescribe prescriptions. The final result is that the secret recipe passed down from generation to generation is invalid." Li Shizhen sighed helplessly.
"This, it seems that we need to find an organization to promote it vigorously. Didn't you work at Tai Hospital? Can't it be done at Tai Hospital? They are responsible for royal security. There must be a need to do this. This matter , maybe there is a way." Gao Hanwen contacted the future project contracting ideas and immediately thought of a solution.
When scholars want to do something, they need to help leaders first think of a necessary demand, and then seek policy support so that the project can be implemented and the matter can be realized. You must know that the routines of later generations are inherited from ancient times. This routine was definitely similar in the Ming Dynasty.
"This, just because I come from a family of imperial doctors, it is absolutely impossible for me to propose such a proposal. Once it is proposed, what if the prescription and medicine are found to be ineffective? What should I do if the ineffective prescription is used to deceive the emperor?" Those crimes are all punishable by death. Mr. Gao, you have already implemented "changing rice into mulberry". Can you also give me some feasible suggestions?"
Li Shizhen said it. With his own difficulties, he was waiting for Gao Hanwen's advice.
Theoretically, compared to changing rice to mulberry, this joint medical and drug testing is not a piece of cake.
However, things that are hard on the people can still be implemented with all their strength, but things that are hard on the bureaucracy are about to explode at the first touch. Even if this bureaucrat is a low-level medical officer.
Gao Hanwen, who realized the difference between ancient and modern times, found that he had indeed made a mistake. It is true that Li Shizhen is a miracle doctor, but this does not mean that it must be at the expense of all his interpersonal relationships. What's more, this is probably a real physical sacrifice.
The key to this issue lies in the characterization of the problem.
If Jiajing characterized the problem as the Taiyuan Hospital knowingly failing to do anything before and deliberately giving fake medicine to the royal family, then death would be inevitable.
If Jiajing defines the problem as the stage limitation of the entire medical development in the general environment, and it is a problem that no one has thought of, then there may be a turning point.
The key is to guide the old Jiajing Taoist priests in a qualitative direction on this matter.
"Well, this matter is really difficult. In this way, you are with meI want to stay here for a few more days, and I'm not in a hurry. Apart from this, are there any methodological problems?" Gao Hanwen had to admit that if he was asked to come up with a plan immediately, I couldn't do it. But we can still continue the discussion if we consider something specific.
" Another problem is that one disease can correspond to multiple diseases, one prescription can cure multiple diseases, and multiple prescriptions can also treat the same disease. In addition, the relationship between individual medicinal materials and combinations of prescriptions is also difficult to define. Therefore, if it is accurately determined that a certain side drug can best treat a certain type of disease, and how to clearly explain the interaction of the medicinal materials in the prescription. Since Mr. Gao proposed logic, if we don’t use Yin Yang and Five Elements here, we have to borrow the knowledge of Mr. Gao.”
This question is actually quite acute. Many times, we only need to repeat experiments to verify a question. . But some problems cannot be verified by repeated experiments. The typical problem is the endogeneity problem. I was very frustrated by this when I was writing my graduation thesis. Is it because the teacher’s requirements are so strict?
Unexpectedly, the Ming Dynasty would have to encounter this problem. Although I don’t know about the large-sample double-blind experiments in the medical profession, the logic should be similar. The most critical test for endogeneity problems in accounting is sample and model design. < /p>
So first we have to find patients with similar conditions, preferably similar age, physical condition, disease history, etc. Then there is the process of constructing diddifferendifference, that is, some patients only use licorice water as a placebo. , part of the treatment.
In the first step of this treatment process, first verify whether the prescription is effective through a large sample.
The second step is to use the original prescription to treat the patient. When the control group is used, eliminate or modify the dosage of each ingredient in the prescription one by one to lock in the effect of each medicinal material and obtain a refined prescription.
The third step is to determine the refined prescription. The people treated by the refined prescription are used as a control. The medicinal materials in the refined prescription are replaced one by one with similar medicinal materials in traditional Chinese medicine. The new prescription with the best efficacy is selected, and the first two steps are repeated to obtain the second refined prescription.
The fourth step is to determine the interrelationship and efficacy logic of each medicinal material through whether the medicinal materials can be substituted for each other and the magnitude of their efficacy after substitution.
"Master Gao is really thoughtful, I admire you. Gao Daren's method will certainly benefit not only medicine, but other disciplines as well. Mr. Gao, please allow me, Li Shizhen, courtesy name Dongbi, to conduct the disciple ceremony. Teacher Gao, please bow to me as a disciple, and I will offer you Shu Xiu tonight." As soon as Gao Hanwen finished speaking, Li Shizhen knelt down directly.
He really knelt down, and Gao Hanwen didn't even stop him. They had no choice but to kneel down.
The two grown men were kneeling opposite each other in the yamen. Xu Youzhi, who was watching this from outside, did not come in to interrupt.
"Teacher Gao, hurry up. Get up, otherwise I will never be able to kneel down. There is no order of learning, the master is the teacher. Since the "Treatise on Injury and Miscellaneous Diseases" by Dr. Zhang in the Han Dynasty, how has medicine diagnosed diseases and prescribed prescriptions?, the drug test has been pending, and in the end we can only keep it secret and rely on the mysterious and mysterious Yin-Yang and Five Elements. Mr. Gao's words can lead to great harm. If God does not give birth to Mr. Gao, medicine will last forever like a long night. The teacher is to medicine what the sage Confucius is to Confucianism. It is natural for me to become a teacher today, and secondly, I can confirm and practice the teacher’s theory in the future. "
Li Shizhen knelt down with runny nose and tears to help Gao Hanwen. Gao Hanwen was tortured and persuaded. Although he was a bit of a high hat, it was not a problem for a big brother in his forties to kneel like this. . Just get up.
As soon as he got up, Gao Hanwen wanted to help Li Shizhen, but Li Shizhen took advantage of the situation and kowtowed three times.
"Don't look outside, what's going on here?" Gao Hanwen was a little at a loss, so he simply called Xu Youzhi in to change the subject.
" With a creak, Xu Youzhi crept in as if he had made a mistake. .
"That Italian Nado, that's his name, I guess, won't be back tonight. I heard that Eunuch Yang from the Manufacturing Bureau is interested in the countries in Europe and the West, so I invited him over this afternoon."
"Is that so? Eunuch Yang didn't ask Old Man Yu or Guo Xiaozi to be the translators?" Gao Hanwen suddenly became curious.
"No, I just asked Naduo to come over alone." Xu Youzhi replied briefly, with the self-consciousness of a life secretary.
Li Shizhen was still kneeling on the ground at this time. She didn’t dare to get up even if the teacher didn’t shout. She just heard that the topic had changed. She was a little confused and asked, “Teacher, my little wife, it’s about the barbarians from the West.”
"Haha, it's not a loss if you kneel a little longer. Your affairs may have to rely on the opportunity of this barbarian in the West. In the future, don't call others barbarians when you ask for help." Gao Hanwen also discovered He had forgotten about this, so he quickly pulled Li Shizhen up, and also quickly changed the subject of the young master's wife's words.
Xu Youzhi was very happy, but he didn’t want to get carried away.
Good guy, this division is growing very fast.
Thank you very much for the warm postman, the monthly ticket for perseverance and guarding against arrogance and impetuosity, the warm postman, the recommendation tickets from book friends such as Yue Xiaoyou, Na Shuyou 20214957 and so on
Today’s exam is finally over , someone in the examination room collapsed during the math three test, and silently wrote the Preface to Prince Teng's Pavilion on the paper, which was a trap. Please remember to collect it, the latest and fastest website is free to read without anti-theft